FHL3 protein (human) - STRING interaction network

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FHL3

Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. (280 aa)

Predicted Functional Partners:

KLF3

0.991

FHL2

0.981

FHL1

0.918

GCM2

0.914

AIMP2

0.906

NUDCD1

0.902

CCAR1

0.882

HIPK1

0.865

ZNF512B

0.816

RAD21

0.806

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIMP2	FHL3	ENSP00000223029	ENSP00000362107	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	0.906
CCAR1	FHL3	ENSP00000265872	ENSP00000362107	Cell division cycle and apoptosis regulator protein 1; Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apopto [...]	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	0.882
FHL1	FHL2	ENSP00000498684	ENSP00000386892	Four and a half LIM domains protein 1; May have an involvement in muscle development or hypertrophy.	Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes.	0.951
FHL1	FHL3	ENSP00000498684	ENSP00000362107	Four and a half LIM domains protein 1; May have an involvement in muscle development or hypertrophy.	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	0.918
FHL2	FHL1	ENSP00000386892	ENSP00000498684	Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes.	Four and a half LIM domains protein 1; May have an involvement in muscle development or hypertrophy.	0.951
FHL2	FHL3	ENSP00000386892	ENSP00000362107	Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes.	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	0.981
FHL3	AIMP2	ENSP00000362107	ENSP00000223029	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.	0.906
FHL3	CCAR1	ENSP00000362107	ENSP00000265872	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	Cell division cycle and apoptosis regulator protein 1; Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apopto [...]	0.882
FHL3	FHL1	ENSP00000362107	ENSP00000498684	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	Four and a half LIM domains protein 1; May have an involvement in muscle development or hypertrophy.	0.918
FHL3	FHL2	ENSP00000362107	ENSP00000386892	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes.	0.981
FHL3	GCM2	ENSP00000362107	ENSP00000368805	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	Chorion-specific transcription factor GCMb; Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.	0.914
FHL3	HIPK1	ENSP00000362107	ENSP00000407442	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	Homeodomain-interacting protein kinase 1; Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by [...]	0.865
FHL3	KLF3	ENSP00000362107	ENSP00000261438	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	Krueppel-like factor 3; Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family.	0.991
FHL3	NUDCD1	ENSP00000362107	ENSP00000239690	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	NudC domain containing 1.	0.902
FHL3	RAD21	ENSP00000362107	ENSP00000297338	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	Double-strand-break repair protein rad21 homolog; [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. In interphase, cohesins may function in the control of gene expression by binding to n [...]	0.806
FHL3	ZNF512B	ENSP00000362107	ENSP00000358904	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	Zinc finger protein 512B; May be involved in transcriptional regulation.	0.816
GCM2	FHL3	ENSP00000368805	ENSP00000362107	Chorion-specific transcription factor GCMb; Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	0.914
HIPK1	FHL3	ENSP00000407442	ENSP00000362107	Homeodomain-interacting protein kinase 1; Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by [...]	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	0.865
KLF3	FHL3	ENSP00000261438	ENSP00000362107	Krueppel-like factor 3; Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family.	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	0.991
NUDCD1	FHL3	ENSP00000239690	ENSP00000362107	NudC domain containing 1.	Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.	0.902