Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H4C2H4 clustered histone 2. (103 aa)    
Predicted Functional Partners:
H3C1
H3 clustered histone 1.
 
 
 
 0.982
H3C11
H3 clustered histone 11.
 
 
 
 0.981
H2BC7
H2B clustered histone 7.
 
 
 
 0.974
H4C13
H4 clustered histone 13.
  
  
0.974
H3C7
H3 clustered histone 7.
 
 
 
 0.974
H2BC10
H2B clustered histone 10.
 
 
 
 0.973
H2AC4
H2A clustered histone 4.
   
 
 0.972
H3C2
H3 clustered histone 2.
 
 
 
 0.971
H2BC13
Histone H2B type 1-L; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 
 
 0.969
H3C4
H3 clustered histone 4.
 
 
 
 0.969
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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