AKAP4 protein (human) - STRING interaction network

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AKAP4

A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family. (854 aa)

Predicted Functional Partners:

PRKAR1A

0.980

AKAP3

0.974

PRKAR2A

0.959

PRKACG

0.955

PRKACA

0.954

PRKACB

0.953

AKAP14

0.941

PRKAR2B

0.922

SPACA1

0.912

PRKAR1B

0.909

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP14	AKAP4	ENSP00000360485	ENSP00000351327	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them.	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	0.941
AKAP14	PRKACA	ENSP00000360485	ENSP00000309591	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.999
AKAP14	PRKACB	ENSP00000360485	ENSP00000359719	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.998
AKAP14	PRKACG	ENSP00000360485	ENSP00000366488	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them.	cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus.	0.999
AKAP14	PRKAR1A	ENSP00000360485	ENSP00000376475	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them.	cAMP-dependent protein kinase type I-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.	0.901
AKAP14	PRKAR1B	ENSP00000360485	ENSP00000385749	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them.	cAMP-dependent protein kinase type I-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.	0.905
AKAP14	PRKAR2A	ENSP00000360485	ENSP00000265563	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them.	cAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.	0.999
AKAP14	PRKAR2B	ENSP00000360485	ENSP00000265717	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them.	cAMP-dependent protein kinase type II-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.	0.999
AKAP3	AKAP4	ENSP00000228850	ENSP00000351327	A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	0.974
AKAP3	PRKACA	ENSP00000228850	ENSP00000309591	A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.571
AKAP3	PRKACB	ENSP00000228850	ENSP00000359719	A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.570
AKAP3	PRKACG	ENSP00000228850	ENSP00000366488	A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.	cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus.	0.578
AKAP3	PRKAR1A	ENSP00000228850	ENSP00000376475	A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.	cAMP-dependent protein kinase type I-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.	0.839
AKAP3	PRKAR2A	ENSP00000228850	ENSP00000265563	A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.	cAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.	0.858
AKAP3	SPACA1	ENSP00000228850	ENSP00000237201	A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.	Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility.	0.933
AKAP4	AKAP14	ENSP00000351327	ENSP00000360485	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them.	0.941
AKAP4	AKAP3	ENSP00000351327	ENSP00000228850	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.	0.974
AKAP4	PRKACA	ENSP00000351327	ENSP00000309591	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.954
AKAP4	PRKACB	ENSP00000351327	ENSP00000359719	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.953
AKAP4	PRKACG	ENSP00000351327	ENSP00000366488	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.	cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus.	0.955