| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALS2 | ALS2CL | ENSP00000264276 | ENSP00000313670 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. | 0.580 |
| ALS2 | EEA1 | ENSP00000264276 | ENSP00000317955 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | 0.780 |
| ALS2 | RAB5A | ENSP00000264276 | ENSP00000273047 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.997 |
| ALS2 | RAB5C | ENSP00000264276 | ENSP00000447053 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.540 |
| ALS2 | RABGEF1 | ENSP00000264276 | ENSP00000370208 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). | 0.680 |
| ALS2 | RABIF | ENSP00000264276 | ENSP00000356231 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Guanine nucleotide exchange factor MSS4; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport; Belongs to the DSS4/MSS4 family. | 0.728 |
| ALS2 | RIN1 | ENSP00000264276 | ENSP00000310406 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Ras and Rab interactor 1; Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Belongs to the RIN (Ras interaction/interfe [...] | 0.596 |
| ALS2 | RIN3 | ENSP00000264276 | ENSP00000216487 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function; Belongs to the RIN (Ras interaction/interference) family. | 0.588 |
| ALS2 | RINL | ENSP00000264276 | ENSP00000467107 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | Ras and Rab interactor-like protein; Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity). | 0.534 |
| ALS2CL | ALS2 | ENSP00000313670 | ENSP00000264276 | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | 0.580 |
| ALS2CL | EEA1 | ENSP00000313670 | ENSP00000317955 | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | 0.700 |
| ALS2CL | RAB31 | ENSP00000313670 | ENSP00000461945 | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | 0.548 |
| ALS2CL | RAB5A | ENSP00000313670 | ENSP00000273047 | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.885 |
| ALS2CL | RAB5C | ENSP00000313670 | ENSP00000447053 | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. | Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.661 |
| ALS2CL | RABGEF1 | ENSP00000313670 | ENSP00000370208 | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. | Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). | 0.599 |
| ALS2CL | RABIF | ENSP00000313670 | ENSP00000356231 | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. | Guanine nucleotide exchange factor MSS4; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport; Belongs to the DSS4/MSS4 family. | 0.561 |
| ALS2CL | RIN1 | ENSP00000313670 | ENSP00000310406 | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. | Ras and Rab interactor 1; Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Belongs to the RIN (Ras interaction/interfe [...] | 0.660 |
| ALS2CL | RIN3 | ENSP00000313670 | ENSP00000216487 | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. | Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function; Belongs to the RIN (Ras interaction/interference) family. | 0.639 |
| ALS2CL | RINL | ENSP00000313670 | ENSP00000467107 | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. | Ras and Rab interactor-like protein; Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity). | 0.578 |
| EEA1 | ALS2 | ENSP00000317955 | ENSP00000264276 | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). | 0.780 |
