ANXA2R protein (human) - STRING interaction network

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ANXA2R

Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation. (193 aa)

Predicted Functional Partners:

ANXA2

0.849

S100A10

0.738

KRTAP12-4

0.549

NMS

0.485

TMLHE

0.400

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA2	ANXA2R	ENSP00000346032	ENSP00000315915	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.	0.849
ANXA2	S100A10	ENSP00000346032	ENSP00000357801	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	0.999
ANXA2R	ANXA2	ENSP00000315915	ENSP00000346032	Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	0.849
ANXA2R	KRTAP12-4	ENSP00000315915	ENSP00000375476	Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.	Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	0.549
ANXA2R	NMS	ENSP00000315915	ENSP00000366061	Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.	Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family.	0.485
ANXA2R	S100A10	ENSP00000315915	ENSP00000357801	Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	0.738
ANXA2R	TMLHE	ENSP00000315915	ENSP00000335261	Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.	Trimethyllysine dioxygenase, mitochondrial; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).	0.400
KRTAP12-4	ANXA2R	ENSP00000375476	ENSP00000315915	Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.	0.549
KRTAP12-4	NMS	ENSP00000375476	ENSP00000366061	Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family.	0.642
NMS	ANXA2R	ENSP00000366061	ENSP00000315915	Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family.	Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.	0.485
NMS	KRTAP12-4	ENSP00000366061	ENSP00000375476	Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family.	Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 12 family.	0.642
S100A10	ANXA2	ENSP00000357801	ENSP00000346032	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.	0.999
S100A10	ANXA2R	ENSP00000357801	ENSP00000315915	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family.	Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.	0.738
TMLHE	ANXA2R	ENSP00000335261	ENSP00000315915	Trimethyllysine dioxygenase, mitochondrial; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).	Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.	0.400