| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOL4 | APOL5 | ENSP00000338260 | ENSP00000249044 | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | Apolipoprotein L5; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | 0.401 |
| APOL4 | APOL6 | ENSP00000338260 | ENSP00000386280 | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | 0.486 |
| APOL4 | CHRM4 | ENSP00000338260 | ENSP00000409378 | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. | 0.515 |
| APOL4 | COMT | ENSP00000338260 | ENSP00000354511 | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.726 |
| APOL4 | LOC102724788 | ENSP00000338260 | ENSP00000481127 | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | 0.504 |
| APOL4 | NPIPB9 | ENSP00000338260 | ENSP00000446902 | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | Nuclear pore complex interacting protein family member B9; Belongs to the NPIP family. | 0.402 |
| APOL4 | OR10H1 | ENSP00000338260 | ENSP00000493436 | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | Olfactory receptor 10H1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.415 |
| APOL4 | OR10H5 | ENSP00000338260 | ENSP00000493242 | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | Olfactory receptor 10H5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.463 |
| APOL4 | PDE4B | ENSP00000338260 | ENSP00000342637 | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | cAMP-specific 3',5'-cyclic phosphodiesterase 4B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. | 0.436 |
| APOL4 | PRODH | ENSP00000338260 | ENSP00000349577 | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.497 |
| APOL5 | APOL4 | ENSP00000249044 | ENSP00000338260 | Apolipoprotein L5; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | 0.401 |
| APOL5 | COMT | ENSP00000249044 | ENSP00000354511 | Apolipoprotein L5; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.671 |
| APOL6 | APOL4 | ENSP00000386280 | ENSP00000338260 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | 0.486 |
| APOL6 | COMT | ENSP00000386280 | ENSP00000354511 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.759 |
| CHRM4 | APOL4 | ENSP00000409378 | ENSP00000338260 | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | 0.515 |
| CHRM4 | PDE4B | ENSP00000409378 | ENSP00000342637 | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. | cAMP-specific 3',5'-cyclic phosphodiesterase 4B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. | 0.487 |
| COMT | APOL4 | ENSP00000354511 | ENSP00000338260 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity). | 0.726 |
| COMT | APOL5 | ENSP00000354511 | ENSP00000249044 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Apolipoprotein L5; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | 0.671 |
| COMT | APOL6 | ENSP00000354511 | ENSP00000386280 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. | 0.759 |
| COMT | LOC102724788 | ENSP00000354511 | ENSP00000481127 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. | 0.793 |
