Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ARGFXArginine-fifty homeobox; Putative transcription factor. (315 aa)    
Predicted Functional Partners:
TPRX1
Tetrapeptide repeat homeobox 1.
   
 
 0.790
DUXA
Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.
   
 
 0.732
DUXB
Double homeobox B.
    
 
 0.679
NANOGNB
NANOG neighbor homeobox.
   
  
 0.587
KLF17
Krueppel-like factor 17; Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).
   
 
 0.571
VENTX
Homeobox protein VENTX; May be involved in ventralization.
      
 0.564
RHOXF2B
Rhox homeobox family member 2B; Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis. Belongs to the paired-like homeobox family. PEPP subfamily.
    
 
 0.563
KHDC1L
Putative KHDC1-like protein; KH domain containing 1 like; Belongs to the KHDC1 family.
      
 0.527
KHDC1
KH homology domain-containing protein 1; KH domain containing 1; Belongs to the KHDC1 family.
      
 0.463
LEUTX
Leucine twenty homeobox.
   
  
0.449
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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