Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ATAD2BATPase family AAA domain containing 2B. (1458 aa)    
Predicted Functional Partners:
H4C6
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 
 0.941
H4C11
H4 clustered histone 11.
    
 
 0.923
H4C2
H4 clustered histone 2.
    
 
 0.923
H4C3
H4 clustered histone 3.
    
 
 0.923
H4-16
H4 histone 16.
    
 
 0.923
H4C15
H4 clustered histone 15.
    
 
 0.923
H4C14
H4 clustered histone 14.
    
 
 0.923
H4C1
H4 clustered histone 1.
    
 
 0.923
H4C4
H4 clustered histone 4.
    
 
 0.923
H4C12
H4 clustered histone 12.
    
 
 0.923
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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