BTF3L4 protein (human) - STRING interaction network

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Score

BTF3L4

Basic transcription factor 3 like 4; Belongs to the NAC-beta family. (158 aa)

Predicted Functional Partners:

BTF3

0.999

RPL31

0.999

NACA

0.999

RPS19

0.966

RPL23A

0.948

RPS8

0.939

NACA2

0.928

RPS15

0.927

RPL21

0.923

RPS12

0.922

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTF3	BTF3L4	ENSP00000369965	ENSP00000360664	Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	Basic transcription factor 3 like 4; Belongs to the NAC-beta family.	0.999
BTF3	NACA	ENSP00000369965	ENSP00000448035	Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	Nascent polypeptide associated complex subunit alpha.	0.999
BTF3	NACA2	ENSP00000369965	ENSP00000427802	Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	Nascent polypeptide-associated complex subunit alpha-2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).	0.981
BTF3	RPL21	ENSP00000369965	ENSP00000346027	Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	60S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family.	0.984
BTF3	RPL23A	ENSP00000369965	ENSP00000389103	Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family.	0.996
BTF3	RPL31	ENSP00000369965	ENSP00000386717	Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	Ribosomal protein L31.	0.999
BTF3	RPS12	ENSP00000369965	ENSP00000230050	Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	Ribosomal protein S12.	0.970
BTF3	RPS15	ENSP00000369965	ENSP00000466010	Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	Ribosomal protein S15.	0.987
BTF3	RPS19	ENSP00000369965	ENSP00000470972	Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	40S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family.	0.993
BTF3	RPS8	ENSP00000369965	ENSP00000379888	Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.	0.989
BTF3L4	BTF3	ENSP00000360664	ENSP00000369965	Basic transcription factor 3 like 4; Belongs to the NAC-beta family.	Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.	0.999
BTF3L4	NACA	ENSP00000360664	ENSP00000448035	Basic transcription factor 3 like 4; Belongs to the NAC-beta family.	Nascent polypeptide associated complex subunit alpha.	0.999
BTF3L4	NACA2	ENSP00000360664	ENSP00000427802	Basic transcription factor 3 like 4; Belongs to the NAC-beta family.	Nascent polypeptide-associated complex subunit alpha-2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).	0.928
BTF3L4	RPL21	ENSP00000360664	ENSP00000346027	Basic transcription factor 3 like 4; Belongs to the NAC-beta family.	60S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family.	0.923
BTF3L4	RPL23A	ENSP00000360664	ENSP00000389103	Basic transcription factor 3 like 4; Belongs to the NAC-beta family.	60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family.	0.948
BTF3L4	RPL31	ENSP00000360664	ENSP00000386717	Basic transcription factor 3 like 4; Belongs to the NAC-beta family.	Ribosomal protein L31.	0.999
BTF3L4	RPS12	ENSP00000360664	ENSP00000230050	Basic transcription factor 3 like 4; Belongs to the NAC-beta family.	Ribosomal protein S12.	0.922
BTF3L4	RPS15	ENSP00000360664	ENSP00000466010	Basic transcription factor 3 like 4; Belongs to the NAC-beta family.	Ribosomal protein S15.	0.927
BTF3L4	RPS19	ENSP00000360664	ENSP00000470972	Basic transcription factor 3 like 4; Belongs to the NAC-beta family.	40S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family.	0.966
BTF3L4	RPS8	ENSP00000360664	ENSP00000379888	Basic transcription factor 3 like 4; Belongs to the NAC-beta family.	Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.	0.939