Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
C22orf15Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15. (157 aa)    
Predicted Functional Partners:
BCAS3
Breast carcinoma-amplified sequence 3; Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor- responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin; Belongs to the BCAS3 family.
    
   0.698
LIMK1
LIM domain kinase 1; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In [...]
    
   0.607
LRRC75B
Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B.
      
 0.496
RGL4
Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4.
   
  
 0.476
FAM227B
Protein FAM227B; Family with sequence similarity 227 member B.
   
  
 0.461
C19orf18
Uncharacterized protein C19orf18; Chromosome 19 open reading frame 18.
   
  
 0.453
DRICH1
Aspartate-rich protein 1; Aspartate rich 1.
   
  
 0.450
DGCR2
Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration.
   
  
 0.445
C12orf43
Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.
      
 0.434
NUTM2D
NUT family member 2D; Belongs to the NUT family.
      
 0.430
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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