C2orf66 protein (human) - STRING interaction network

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C2orf66

Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66. (117 aa)

Predicted Functional Partners:

TMED10

0.766

GANAB

0.549

UGGT1

0.452

UGGT2

0.452

CPVL

0.452

SEC13

0.448

TMEM217

0.444

ZNF561

0.429

CCDC190

0.429

PIGG

0.428

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C2orf66	CCDC190	ENSP00000500939	ENSP00000356886	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	Coiled-coil domain containing 190.	0.429
C2orf66	CPVL	ENSP00000500939	ENSP00000387164	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation; Belongs to the peptidase S10 family.	0.452
C2orf66	GANAB	ENSP00000500939	ENSP00000340466	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	Neutral alpha-glucosidase AB; Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia ; Belongs to the glycosyl hydrolase 31 family.	0.549
C2orf66	PIGG	ENSP00000500939	ENSP00000415203	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.	0.428
C2orf66	SEC13	ENSP00000500939	ENSP00000373312	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity); Belongs to the WD repeat SEC13 family.	0.448
C2orf66	TMED10	ENSP00000500939	ENSP00000303145	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...]	0.766
C2orf66	TMEM217	ENSP00000500939	ENSP00000338164	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	Transmembrane protein 217.	0.444
C2orf66	UGGT1	ENSP00000500939	ENSP00000259253	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	UDP-glucose:glycoprotein glucosyltransferase 1; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.	0.452
C2orf66	UGGT2	ENSP00000500939	ENSP00000365938	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	UDP-glucose:glycoprotein glucosyltransferase 2; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family.	0.452
C2orf66	ZNF561	ENSP00000500939	ENSP00000303915	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	Zinc finger protein 561; May be involved in transcriptional regulation.	0.429
CCDC190	C2orf66	ENSP00000356886	ENSP00000500939	Coiled-coil domain containing 190.	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	0.429
CPVL	C2orf66	ENSP00000387164	ENSP00000500939	Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation; Belongs to the peptidase S10 family.	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	0.452
CPVL	UGGT2	ENSP00000387164	ENSP00000365938	Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation; Belongs to the peptidase S10 family.	UDP-glucose:glycoprotein glucosyltransferase 2; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family.	0.532
GANAB	C2orf66	ENSP00000340466	ENSP00000500939	Neutral alpha-glucosidase AB; Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia ; Belongs to the glycosyl hydrolase 31 family.	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	0.549
GANAB	PIGG	ENSP00000340466	ENSP00000415203	Neutral alpha-glucosidase AB; Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia ; Belongs to the glycosyl hydrolase 31 family.	GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.	0.875
GANAB	UGGT1	ENSP00000340466	ENSP00000259253	Neutral alpha-glucosidase AB; Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia ; Belongs to the glycosyl hydrolase 31 family.	UDP-glucose:glycoprotein glucosyltransferase 1; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.	0.928
GANAB	UGGT2	ENSP00000340466	ENSP00000365938	Neutral alpha-glucosidase AB; Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia ; Belongs to the glycosyl hydrolase 31 family.	UDP-glucose:glycoprotein glucosyltransferase 2; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family.	0.854
PIGG	C2orf66	ENSP00000415203	ENSP00000500939	GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.	Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.	0.428
PIGG	GANAB	ENSP00000415203	ENSP00000340466	GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.	Neutral alpha-glucosidase AB; Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia ; Belongs to the glycosyl hydrolase 31 family.	0.875
PIGG	TMED10	ENSP00000415203	ENSP00000303145	GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.	Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...]	0.902