| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C5orf34 | CCDC124 | ENSP00000303490 | ENSP00000471455 | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages. Belongs to the CCDC124 family. | 0.763 |
| C5orf34 | CDC123 | ENSP00000303490 | ENSP00000281141 | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. | 0.484 |
| C5orf34 | CHMP4B | ENSP00000303490 | ENSP00000217402 | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | 0.457 |
| C5orf34 | CIT | ENSP00000303490 | ENSP00000376306 | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | Citron Rho-interacting kinase; Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. | 0.487 |
| C5orf34 | COPS8 | ENSP00000303490 | ENSP00000346340 | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- [...] | 0.709 |
| C5orf34 | DNAJC7 | ENSP00000303490 | ENSP00000406463 | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | DnaJ homolog subfamily C member 7; Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). | 0.496 |
| C5orf34 | HAAO | ENSP00000303490 | ENSP00000294973 | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | 0.636 |
| C5orf34 | PIK3R5 | ENSP00000303490 | ENSP00000392812 | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | Phosphoinositide 3-kinase regulatory subunit 5; Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein- mediated activation of PIK3CG (By similarity). | 0.498 |
| C5orf34 | PRC1 | ENSP00000303490 | ENSP00000377793 | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | Protein regulator of cytokinesis 1; Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. Belongs to the MAP65/ASE1 [...] | 0.487 |
| C5orf34 | THBS3 | ENSP00000303490 | ENSP00000357362 | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | Thrombospondin-3; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. | 0.608 |
| CCDC124 | C5orf34 | ENSP00000471455 | ENSP00000303490 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages. Belongs to the CCDC124 family. | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | 0.763 |
| CCDC124 | COPS8 | ENSP00000471455 | ENSP00000346340 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages. Belongs to the CCDC124 family. | COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- [...] | 0.646 |
| CCDC124 | HAAO | ENSP00000471455 | ENSP00000294973 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages. Belongs to the CCDC124 family. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | 0.558 |
| CCDC124 | PIK3R5 | ENSP00000471455 | ENSP00000392812 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages. Belongs to the CCDC124 family. | Phosphoinositide 3-kinase regulatory subunit 5; Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein- mediated activation of PIK3CG (By similarity). | 0.429 |
| CDC123 | C5orf34 | ENSP00000281141 | ENSP00000303490 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | 0.484 |
| CDC123 | DNAJC7 | ENSP00000281141 | ENSP00000406463 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. | DnaJ homolog subfamily C member 7; Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). | 0.649 |
| CHMP4B | C5orf34 | ENSP00000217402 | ENSP00000303490 | Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | 0.457 |
| CHMP4B | CIT | ENSP00000217402 | ENSP00000376306 | Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Citron Rho-interacting kinase; Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. | 0.491 |
| CIT | C5orf34 | ENSP00000376306 | ENSP00000303490 | Citron Rho-interacting kinase; Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34. | 0.487 |
| CIT | CHMP4B | ENSP00000376306 | ENSP00000217402 | Citron Rho-interacting kinase; Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. | Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | 0.491 |
