| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGAP39 | C8orf82 | ENSP00000366522 | ENSP00000436621 | Rho GTPase activating protein 39. | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | 0.462 |
| C15orf40 | C8orf82 | ENSP00000403987 | ENSP00000436621 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | 0.460 |
| C15orf40 | ZRANB1 | ENSP00000403987 | ENSP00000352676 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family. | 0.457 |
| C8orf33 | C8orf82 | ENSP00000330361 | ENSP00000436621 | UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family. | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | 0.453 |
| C8orf33 | ZRANB1 | ENSP00000330361 | ENSP00000352676 | UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family. | Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family. | 0.457 |
| C8orf82 | ARHGAP39 | ENSP00000436621 | ENSP00000366522 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | Rho GTPase activating protein 39. | 0.462 |
| C8orf82 | C15orf40 | ENSP00000436621 | ENSP00000403987 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | 0.460 |
| C8orf82 | C8orf33 | ENSP00000436621 | ENSP00000330361 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family. | 0.453 |
| C8orf82 | CLPP | ENSP00000436621 | ENSP00000245816 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | ATP-dependent Clp protease proteolytic subunit, mitochondrial; Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. | 0.596 |
| C8orf82 | ETFA | ENSP00000436621 | ENSP00000452762 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | 0.986 |
| C8orf82 | ETFB | ENSP00000436621 | ENSP00000346173 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. | 0.903 |
| C8orf82 | MRPS27 | ENSP00000436621 | ENSP00000426941 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | 28S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Involved also in positive regulation of cell proliferation and tumor cell growth. | 0.479 |
| C8orf82 | TRIM49C | ENSP00000436621 | ENSP00000388299 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | Tripartite motif containing 49C. | 0.490 |
| C8orf82 | TRIM67 | ENSP00000436621 | ENSP00000355613 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | 0.460 |
| C8orf82 | ZRANB1 | ENSP00000436621 | ENSP00000352676 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family. | 0.457 |
| CLPP | C8orf82 | ENSP00000245816 | ENSP00000436621 | ATP-dependent Clp protease proteolytic subunit, mitochondrial; Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | 0.596 |
| CLPP | ETFA | ENSP00000245816 | ENSP00000452762 | ATP-dependent Clp protease proteolytic subunit, mitochondrial; Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | 0.471 |
| CLPP | ETFB | ENSP00000245816 | ENSP00000346173 | ATP-dependent Clp protease proteolytic subunit, mitochondrial; Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. | 0.756 |
| CLPP | TRIM67 | ENSP00000245816 | ENSP00000355613 | ATP-dependent Clp protease proteolytic subunit, mitochondrial; Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | 0.457 |
| ETFA | C8orf82 | ENSP00000452762 | ENSP00000436621 | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82. | 0.986 |
