Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CCDC59Thyroid transcription factor 1-associated protein 26; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities. (241 aa)    
Predicted Functional Partners:
RPL26L1
Ribosomal protein L26 like 1; Belongs to the universal ribosomal protein uL24 family.
   
   0.917
TTF1
Transcription termination factor 1; Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.
   
 
  0.906
RPL36AL
Ribosomal protein L36a like; Belongs to the eukaryotic ribosomal protein eL42 family.
   
   0.867
RPL3
60S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
   
   0.817
SFTPB
Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
     
 0.813
SFTPC
Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
   
 
 0.787
LLPH
Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.
   
    0.735
MRPS31
Mitochondrial ribosomal protein S31.
   
   0.647
MRPS5
Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.
   
   0.580
NPM3
Nucleoplasmin-3; Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM ; Belongs to the nucleoplasmin family.
   
   0.571
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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