CCDC86 protein (human) - STRING interaction network

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[Homology]

Score

CCDC86

Coiled-coil domain containing 86. (360 aa)

Predicted Functional Partners:

MRTO4

0.989

NSA2

0.977

RRS1

0.882

RPF2

0.879

NIFK

0.871

GNL3

0.866

LLPH

0.863

ZNF593

0.851

NIP7

0.850

SDAD1

0.846

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC86	GNL3	ENSP00000227520	ENSP00000395772	Coiled-coil domain containing 86.	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family.	0.866
CCDC86	LLPH	ENSP00000227520	ENSP00000266604	Coiled-coil domain containing 86.	Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.	0.863
CCDC86	MRTO4	ENSP00000227520	ENSP00000364320	Coiled-coil domain containing 86.	mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.989
CCDC86	NIFK	ENSP00000227520	ENSP00000285814	Coiled-coil domain containing 86.	Nucleolar protein interacting with the FHA domain of MKI67.	0.871
CCDC86	NIP7	ENSP00000227520	ENSP00000254940	Coiled-coil domain containing 86.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.850
CCDC86	NSA2	ENSP00000227520	ENSP00000483484	Coiled-coil domain containing 86.	Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).	0.977
CCDC86	RPF2	ENSP00000227520	ENSP00000402338	Coiled-coil domain containing 86.	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.	0.879
CCDC86	RRS1	ENSP00000227520	ENSP00000322396	Coiled-coil domain containing 86.	Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RRS1 family.	0.882
CCDC86	SDAD1	ENSP00000227520	ENSP00000348596	Coiled-coil domain containing 86.	Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.	0.846
CCDC86	ZNF593	ENSP00000227520	ENSP00000363384	Coiled-coil domain containing 86.	Zinc finger protein 593; Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.	0.851
GNL3	CCDC86	ENSP00000395772	ENSP00000227520	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family.	Coiled-coil domain containing 86.	0.866
GNL3	LLPH	ENSP00000395772	ENSP00000266604	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family.	Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.	0.840
GNL3	MRTO4	ENSP00000395772	ENSP00000364320	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family.	mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.995
GNL3	NIFK	ENSP00000395772	ENSP00000285814	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family.	Nucleolar protein interacting with the FHA domain of MKI67.	0.997
GNL3	NIP7	ENSP00000395772	ENSP00000254940	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.990
GNL3	NSA2	ENSP00000395772	ENSP00000483484	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family.	Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).	0.989
GNL3	RPF2	ENSP00000395772	ENSP00000402338	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family.	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.	0.995
GNL3	RRS1	ENSP00000395772	ENSP00000322396	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family.	Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RRS1 family.	0.988
GNL3	SDAD1	ENSP00000395772	ENSP00000348596	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family.	Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.	0.994
GNL3	ZNF593	ENSP00000395772	ENSP00000363384	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family.	Zinc finger protein 593; Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.	0.978