| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARL2 | ARL3 | ENSP00000246747 | ENSP00000260746 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | 0.772 |
| ARL2 | CFAP36 | ENSP00000246747 | ENSP00000342699 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.653 |
| ARL3 | ARL2 | ENSP00000260746 | ENSP00000246747 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | 0.772 |
| ARL3 | CFAP36 | ENSP00000260746 | ENSP00000342699 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.960 |
| CCDC63 | CFAP36 | ENSP00000312399 | ENSP00000342699 | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.522 |
| CCDC63 | RIBC2 | ENSP00000312399 | ENSP00000483356 | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. | RIB43A domain with coiled-coils 2. | 0.806 |
| CCDC63 | TTC29 | ENSP00000312399 | ENSP00000423505 | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. | Tetratricopeptide repeat domain 29. | 0.811 |
| CFAP36 | ARL2 | ENSP00000342699 | ENSP00000246747 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] | 0.653 |
| CFAP36 | ARL3 | ENSP00000342699 | ENSP00000260746 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | 0.960 |
| CFAP36 | CCDC63 | ENSP00000342699 | ENSP00000312399 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. | 0.522 |
| CFAP36 | CNOT10 | ENSP00000342699 | ENSP00000399862 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex. | 0.495 |
| CFAP36 | FAM161B | ENSP00000342699 | ENSP00000499021 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | FAM161 centrosomal protein B; Belongs to the FAM161 family. | 0.560 |
| CFAP36 | FAM81B | ENSP00000342699 | ENSP00000283357 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Protein FAM81B; Family with sequence similarity 81 member B. | 0.542 |
| CFAP36 | IWS1 | ENSP00000342699 | ENSP00000295321 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Protein IWS1 homolog; Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) [...] | 0.493 |
| CFAP36 | RIBC2 | ENSP00000342699 | ENSP00000483356 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | RIB43A domain with coiled-coils 2. | 0.481 |
| CFAP36 | TTC29 | ENSP00000342699 | ENSP00000423505 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Tetratricopeptide repeat domain 29. | 0.531 |
| CFAP36 | ZCCHC17 | ENSP00000342699 | ENSP00000480986 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Nucleolar protein of 40 kDa; Zinc finger CCHC-type containing 17. | 0.545 |
| CNOT10 | CFAP36 | ENSP00000399862 | ENSP00000342699 | CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex. | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.495 |
| CNOT10 | IWS1 | ENSP00000399862 | ENSP00000295321 | CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex. | Protein IWS1 homolog; Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) [...] | 0.461 |
| CNOT10 | ZCCHC17 | ENSP00000399862 | ENSP00000480986 | CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex. | Nucleolar protein of 40 kDa; Zinc finger CCHC-type containing 17. | 0.456 |
