CLN3 protein (human) - STRING interaction network

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Score

CLN3

Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. (438 aa)

Predicted Functional Partners:

PPT1

0.995

CLN5

0.991

CLN6

0.981

CLN8

0.966

TPP1

0.962

MFSD8

0.949

HMGCL

0.893

DNAJC5

0.871

HMGCLL1

0.867

COX15

0.865

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLN3	CLN5	ENSP00000454229	ENSP00000498772	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	0.991
CLN3	CLN6	ENSP00000454229	ENSP00000249806	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	CLN6 transmembrane ER protein.	0.981
CLN3	CLN8	ENSP00000454229	ENSP00000328182	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.	0.966
CLN3	COX15	ENSP00000454229	ENSP00000016171	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A. Belongs to the COX15/CtaA family.	0.865
CLN3	DNAJC5	ENSP00000454229	ENSP00000354111	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).	0.871
CLN3	HMGCL	ENSP00000454229	ENSP00000363614	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.	0.893
CLN3	HMGCLL1	ENSP00000454229	ENSP00000381654	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.	0.867
CLN3	MFSD8	ENSP00000454229	ENSP00000493218	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients.	0.949
CLN3	PPT1	ENSP00000454229	ENSP00000493153	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons ; Belongs to the palmitoyl-protein thioesterase family.	0.995
CLN3	TPP1	ENSP00000454229	ENSP00000299427	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.	0.962
CLN5	CLN3	ENSP00000498772	ENSP00000454229	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	0.991
CLN5	CLN6	ENSP00000498772	ENSP00000249806	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	CLN6 transmembrane ER protein.	0.992
CLN5	CLN8	ENSP00000498772	ENSP00000328182	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.	0.978
CLN5	DNAJC5	ENSP00000498772	ENSP00000354111	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).	0.851
CLN5	MFSD8	ENSP00000498772	ENSP00000493218	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients.	0.933
CLN5	PPT1	ENSP00000498772	ENSP00000493153	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons ; Belongs to the palmitoyl-protein thioesterase family.	0.975
CLN5	TPP1	ENSP00000498772	ENSP00000299427	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.	0.799
CLN6	CLN3	ENSP00000249806	ENSP00000454229	CLN6 transmembrane ER protein.	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	0.981
CLN6	CLN5	ENSP00000249806	ENSP00000498772	CLN6 transmembrane ER protein.	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	0.992
CLN6	CLN8	ENSP00000249806	ENSP00000328182	CLN6 transmembrane ER protein.	Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.	0.981