CLRN2 protein (human) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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proteins of unknown 3D structure

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[Homology]

Score

CLRN2

Clarin-2; Clarin 2. (232 aa)

Predicted Functional Partners:

CACNG2

0.728

STRC

0.595

GRXCR2

0.538

TMC1

0.523

CEP295NL

0.506

LRRC31

0.497

USH1C

0.491

CHRNA10

0.480

PPP1R17

0.479

ZNF286A

0.479

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNG2	CLRN2	ENSP00000300105	ENSP00000424711	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Clarin-2; Clarin 2.	0.728
CEP295NL	CLRN2	ENSP00000312767	ENSP00000424711	CEP295 N-terminal-like protein; CEP295 N-terminal like.	Clarin-2; Clarin 2.	0.506
CEP295NL	LRRC31	ENSP00000312767	ENSP00000325978	CEP295 N-terminal-like protein; CEP295 N-terminal like.	Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31.	0.541
CHRNA10	CLRN2	ENSP00000250699	ENSP00000424711	Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reduci [...]	Clarin-2; Clarin 2.	0.480
CHRNA10	GRXCR2	ENSP00000250699	ENSP00000367214	Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reduci [...]	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection.	0.493
CHRNA10	PPP1R17	ENSP00000250699	ENSP00000340125	Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reduci [...]	Protein phosphatase 1 regulatory subunit 17; Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.	0.453
CHRNA10	STRC	ENSP00000250699	ENSP00000401513	Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reduci [...]	Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia; Belongs to the stereocilin family.	0.490
CLRN2	CACNG2	ENSP00000424711	ENSP00000300105	Clarin-2; Clarin 2.	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.728
CLRN2	CEP295NL	ENSP00000424711	ENSP00000312767	Clarin-2; Clarin 2.	CEP295 N-terminal-like protein; CEP295 N-terminal like.	0.506
CLRN2	CHRNA10	ENSP00000424711	ENSP00000250699	Clarin-2; Clarin 2.	Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reduci [...]	0.480
CLRN2	GRXCR2	ENSP00000424711	ENSP00000367214	Clarin-2; Clarin 2.	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection.	0.538
CLRN2	LRRC31	ENSP00000424711	ENSP00000325978	Clarin-2; Clarin 2.	Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31.	0.497
CLRN2	PPP1R17	ENSP00000424711	ENSP00000340125	Clarin-2; Clarin 2.	Protein phosphatase 1 regulatory subunit 17; Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.	0.479
CLRN2	STRC	ENSP00000424711	ENSP00000401513	Clarin-2; Clarin 2.	Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia; Belongs to the stereocilin family.	0.595
CLRN2	TMC1	ENSP00000424711	ENSP00000494684	Clarin-2; Clarin 2.	Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family.	0.523
CLRN2	USH1C	ENSP00000424711	ENSP00000005226	Clarin-2; Clarin 2.	Harmonin; USH1 protein network component harmonin.	0.491
CLRN2	ZNF286A	ENSP00000424711	ENSP00000464218	Clarin-2; Clarin 2.	Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.479
GRXCR2	CHRNA10	ENSP00000367214	ENSP00000250699	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection.	Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reduci [...]	0.493
GRXCR2	CLRN2	ENSP00000367214	ENSP00000424711	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection.	Clarin-2; Clarin 2.	0.538
GRXCR2	PPP1R17	ENSP00000367214	ENSP00000340125	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection.	Protein phosphatase 1 regulatory subunit 17; Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.	0.471