COG1 protein (human) - STRING interaction network

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[Homology]

Score

COG1

Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. (980 aa)

Predicted Functional Partners:

COG3

0.999

COG5

0.999

COG7

0.999

COG4

0.999

COG2

0.999

COG6

0.999

COG8

0.999

CDC42

0.936

TMEM115

0.927

PARP16

0.913

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	COG1	ENSP00000497733	ENSP00000299886	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...]	Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.	0.936
CDC42	COG2	ENSP00000497733	ENSP00000355629	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...]	Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family.	0.902
CDC42	COG3	ENSP00000497733	ENSP00000258654	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...]	Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport.	0.905
CDC42	COG4	ENSP00000497733	ENSP00000315775	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...]	Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Belongs to the COG4 family.	0.948
CDC42	COG5	ENSP00000497733	ENSP00000297135	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...]	Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family.	0.969
CDC42	COG6	ENSP00000497733	ENSP00000397441	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...]	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family.	0.911
CDC42	COG7	ENSP00000497733	ENSP00000305442	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...]	Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function.	0.906
CDC42	COG8	ENSP00000497733	ENSP00000497669	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...]	Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function.	0.903
CDC42	TMEM115	ENSP00000497733	ENSP00000266025	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...]	Transmembrane protein 115; May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.	0.900
COG1	CDC42	ENSP00000299886	ENSP00000497733	Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...]	0.936
COG1	COG2	ENSP00000299886	ENSP00000355629	Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.	Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family.	0.999
COG1	COG3	ENSP00000299886	ENSP00000258654	Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.	Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport.	0.999
COG1	COG4	ENSP00000299886	ENSP00000315775	Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.	Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Belongs to the COG4 family.	0.999
COG1	COG5	ENSP00000299886	ENSP00000297135	Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.	Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family.	0.999
COG1	COG6	ENSP00000299886	ENSP00000397441	Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family.	0.999
COG1	COG7	ENSP00000299886	ENSP00000305442	Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.	Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function.	0.999
COG1	COG8	ENSP00000299886	ENSP00000497669	Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.	Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function.	0.999
COG1	PARP16	ENSP00000299886	ENSP00000261888	Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.	Protein mono-ADP-ribosyltransferase PARP16; Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP- ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases.	0.913
COG1	TMEM115	ENSP00000299886	ENSP00000266025	Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.	Transmembrane protein 115; May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.	0.927
COG2	CDC42	ENSP00000355629	ENSP00000497733	Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...]	0.902