Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DAZ2Deleted in azoospermia 2. (558 aa)    
Predicted Functional Partners:
DAZ3
Deleted in azoospermia protein 2; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
  
  
0.978
DAZ1
Deleted in azoospermia protein 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells.
  
  
0.978
CDY1
Testis-specific chromodomain protein Y 1; Has histone acetyltransferase activity, with a preference for histone H4.
    
 
 0.932
CDY2A
Testis-specific chromodomain protein Y 2; May have histone acetyltransferase activity.
   
 
 0.899
BPY2
Basic charge Y-linked 2.
   
  
 0.896
BPY2B
Basic charge Y-linked 2B.
   
  
 0.890
BPY2C
Basic charge Y-linked 2C.
      
 0.888
PRY
PTPN13-like protein, Y-linked; PTPN13 like Y-linked.
      
 0.772
USP9Y
Probable ubiquitin carboxyl-terminal hydrolase FAF-Y; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable co [...]
   
  
 0.770
PRY2
PTPN13 like Y-linked 2.
   
  
 0.769
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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