Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DEFB113Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family. (82 aa)    
Predicted Functional Partners:
DEFB110
Beta-defensin 110; Has antibacterial activity.
   
 
 0.920
CT62
Cancer/testis associated 62.
   
    0.846
DEFB128
Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.837
DEFB121
Beta-defensin 121; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.827
DEFB134
Beta-defensin 134; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.820
DEFB124
Beta-defensin 124; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.797
DEFB126
Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...]
   
 
 0.793
DEFB130B
Defensin beta 130B.
   
 
 0.786
DEFB107A
Beta-defensin 107; Has antibacterial activity.
   
 
 0.777
DEFB123
Beta-defensin 123; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.774
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.