Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DEFB115Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)    
Predicted Functional Partners:
DEFB116
Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.831
DEFB127
Beta-defensin 127; Has antibacterial activity.
   
 
 0.825
DEFB123
Beta-defensin 123; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.817
DEFB121
Beta-defensin 121; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.802
DEFB119
Defensin beta 119.
   
 
 0.801
DEFB110
Beta-defensin 110; Has antibacterial activity.
   
 
 0.788
DEFB130B
Defensin beta 130B.
   
 
 0.788
DEFB128
Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.786
DEFB136
Beta-defensin 136; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.783
DEFB124
Beta-defensin 124; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.770
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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