Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DEFB124Beta-defensin 124; Has antibacterial activity; Belongs to the beta-defensin family. (71 aa)    
Predicted Functional Partners:
ANXA2
Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family.
    
   0.944
DEFB125
Beta-defensin 125; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.901
DEFB135
Beta-defensin 135; Has antibacterial activity; Belongs to the beta-defensin family.
     
 0.897
DEFB128
Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.890
DEFB127
Beta-defensin 127; Has antibacterial activity.
     
 0.838
DEFB114
Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality.
     
 0.836
DEFB134
Beta-defensin 134; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.834
DEFB123
Beta-defensin 123; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.807
DEFB119
Defensin beta 119.
   
 
 0.802
DEFB113
Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
 0.797
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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