| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABHD10 | DIP2A | ENSP00000273359 | ENSP00000392066 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system. | 0.500 |
| ABHD10 | DIP2C | ENSP00000273359 | ENSP00000280886 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Disco interacting protein 2 homolog C. | 0.500 |
| DIP2A | ABHD10 | ENSP00000392066 | ENSP00000273359 | Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system. | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | 0.500 |
| DIP2A | DIP2C | ENSP00000392066 | ENSP00000280886 | Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system. | Disco interacting protein 2 homolog C. | 0.694 |
| DIP2A | DMAP1 | ENSP00000392066 | ENSP00000361363 | Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system. | DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucle [...] | 0.619 |
| DIP2A | FASN | ENSP00000392066 | ENSP00000304592 | Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system. | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. | 0.535 |
| DIP2A | HSDL2 | ENSP00000392066 | ENSP00000381785 | Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system. | Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.615 |
| DIP2A | RANBP2 | ENSP00000392066 | ENSP00000283195 | Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system. | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex [...] | 0.536 |
| DIP2C | ABHD10 | ENSP00000280886 | ENSP00000273359 | Disco interacting protein 2 homolog C. | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | 0.500 |
| DIP2C | DIP2A | ENSP00000280886 | ENSP00000392066 | Disco interacting protein 2 homolog C. | Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system. | 0.694 |
| DIP2C | DMAP1 | ENSP00000280886 | ENSP00000361363 | Disco interacting protein 2 homolog C. | DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucle [...] | 0.608 |
| DIP2C | FASN | ENSP00000280886 | ENSP00000304592 | Disco interacting protein 2 homolog C. | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. | 0.535 |
| DIP2C | HSDL2 | ENSP00000280886 | ENSP00000381785 | Disco interacting protein 2 homolog C. | Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.615 |
| DIP2C | PIP4K2A | ENSP00000280886 | ENSP00000365757 | Disco interacting protein 2 homolog C. | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] | 0.597 |
| DIP2C | PIP4K2C | ENSP00000280886 | ENSP00000347032 | Disco interacting protein 2 homolog C. | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum. | 0.574 |
| DIP2C | RANBP2 | ENSP00000280886 | ENSP00000283195 | Disco interacting protein 2 homolog C. | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex [...] | 0.543 |
| DIP2C | WDR37 | ENSP00000280886 | ENSP00000263150 | Disco interacting protein 2 homolog C. | WD repeat domain 37. | 0.559 |
| DIP2C | ZMYND11 | ENSP00000280886 | ENSP00000371003 | Disco interacting protein 2 homolog C. | Zinc finger MYND domain-containing protein 11; Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. | 0.566 |
| DMAP1 | DIP2A | ENSP00000361363 | ENSP00000392066 | DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucle [...] | Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system. | 0.619 |
| DMAP1 | DIP2C | ENSP00000361363 | ENSP00000280886 | DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucle [...] | Disco interacting protein 2 homolog C. | 0.608 |
