Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DOP1BProtein dopey-2; May be involved in protein traffic between late Golgi and early endosomes. (2298 aa)    
Predicted Functional Partners:
MON2
Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes.
   
 
 0.898
ATP1A1
Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
   
   0.856
SLC66A2
Solute carrier family 66 member 2.
    
 
 0.686
SLC35F2
Solute carrier family 35 member F2; Putative solute transporter.
   
  
 0.669
IMMP2L
Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily.
   
  
 0.545
CRYZL1
Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
   
  
 0.523
ATP9A
Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A.
   
 
 0.498
CHRFAM7A
CHRNA7-FAM7A fusion protein; CHRNA7 fusion.
      
 0.492
MRPS6
Mitochondrial ribosomal protein S6.
      
 0.488
ATP9B
Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B.
   
 
 0.482
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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