Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EMC1ER membrane protein complex subunit 1; Belongs to the EMC1 family. (993 aa)    
Predicted Functional Partners:
EMC2
ER membrane protein complex subunit 2.
   
 0.999
EMC3
ER membrane protein complex subunit 3.
   
 0.999
EMC8
ER membrane protein complex subunit 8.
   
 0.999
EMC7
ER membrane protein complex subunit 7; Belongs to the EMC7 family.
   
 0.999
EMC4
ER membrane protein complex subunit 4; May mediate anti-apoptotic activity.
   
 0.999
MMGT1
Membrane magnesium transporter 1; Mediates Mg(2+) transport; Belongs to the membrane magnesium transporter (TC 1.A.67) family.
   
 0.999
EMC10
ER membrane protein complex subunit 10; Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.
   
 0.999
EMC9
ER membrane protein complex subunit 9.
   
 0.999
EMC6
ER membrane protein complex subunit 6; Belongs to the EMC6 family.
   
 0.998
UBAC2
Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin- mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6.
   
 
 0.940
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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