| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDA | EMP3 | ENSP00000363680 | ENSP00000469194 | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. May also play a role in cell adhesion (By similarity). [Isoform 3]: Binds only to the receptor EDA2R. Belongs to the tumor necrosis factor family. | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | 0.699 |
| EMP3 | EDA | ENSP00000469194 | ENSP00000363680 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. May also play a role in cell adhesion (By similarity). [Isoform 3]: Binds only to the receptor EDA2R. Belongs to the tumor necrosis factor family. | 0.699 |
| EMP3 | FXYD5 | ENSP00000469194 | ENSP00000444839 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | FXYD domain-containing ion transport regulator 5; Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. Belongs to the FXYD family. | 0.529 |
| EMP3 | KLRC1 | ENSP00000469194 | ENSP00000438038 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | NKG2-A/NKG2-B type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | 0.802 |
| EMP3 | LGALS1 | ENSP00000469194 | ENSP00000215909 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | 0.799 |
| EMP3 | LIM2 | ENSP00000469194 | ENSP00000221973 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | 0.728 |
| EMP3 | PLP2 | ENSP00000469194 | ENSP00000365505 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium. | 0.520 |
| EMP3 | S100A4 | ENSP00000469194 | ENSP00000357704 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | S100 calcium binding protein A4. | 0.567 |
| EMP3 | TGFBR2 | ENSP00000469194 | ENSP00000351905 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.918 |
| EMP3 | TIMP1 | ENSP00000469194 | ENSP00000218388 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | 0.495 |
| EMP3 | VIM | ENSP00000469194 | ENSP00000446007 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. | 0.613 |
| FXYD5 | EMP3 | ENSP00000444839 | ENSP00000469194 | FXYD domain-containing ion transport regulator 5; Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. Belongs to the FXYD family. | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | 0.529 |
| FXYD5 | S100A4 | ENSP00000444839 | ENSP00000357704 | FXYD domain-containing ion transport regulator 5; Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. Belongs to the FXYD family. | S100 calcium binding protein A4. | 0.414 |
| KLRC1 | EMP3 | ENSP00000438038 | ENSP00000469194 | NKG2-A/NKG2-B type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | 0.802 |
| LGALS1 | EMP3 | ENSP00000215909 | ENSP00000469194 | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | 0.799 |
| LGALS1 | S100A4 | ENSP00000215909 | ENSP00000357704 | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | S100 calcium binding protein A4. | 0.807 |
| LGALS1 | TIMP1 | ENSP00000215909 | ENSP00000218388 | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | 0.541 |
| LGALS1 | VIM | ENSP00000215909 | ENSP00000446007 | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. | 0.863 |
| LIM2 | EMP3 | ENSP00000221973 | ENSP00000469194 | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | 0.728 |
| PLP2 | EMP3 | ENSP00000365505 | ENSP00000469194 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium. | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | 0.520 |
