| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLASP2 | FAM43A | ENSP00000327760 | ENSP00000371397 | CLIP-associating protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at le [...] | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | 0.422 |
| FAM43A | CLASP2 | ENSP00000371397 | ENSP00000327760 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | CLIP-associating protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at le [...] | 0.422 |
| FAM43A | LSG1 | ENSP00000371397 | ENSP00000265245 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable). | 0.578 |
| FAM43A | PPP2R5A | ENSP00000371397 | ENSP00000261461 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.591 |
| FAM43A | PPP2R5B | ENSP00000371397 | ENSP00000164133 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. | 0.610 |
| FAM43A | PPP2R5C | ENSP00000371397 | ENSP00000412324 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. | 0.465 |
| FAM43A | SFT2D1 | ENSP00000371397 | ENSP00000354590 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | Vesicle transport protein SFT2A; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family. | 0.496 |
| FAM43A | SNX29 | ENSP00000371397 | ENSP00000456480 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | Sorting nexin 29. | 0.479 |
| FAM43A | TMEM44 | ENSP00000371397 | ENSP00000376227 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | Transmembrane protein 44. | 0.509 |
| FAM43A | XXYLT1 | ENSP00000371397 | ENSP00000309640 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | Xyloside xylosyltransferase 1; Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose. Known targets include Notch proteins and coagulation factors, such as F9 ; Belongs to the glycosyltransferase 8 family. | 0.464 |
| FAM43A | ZNF22 | ENSP00000371397 | ENSP00000298299 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | Zinc finger protein 22; Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity). | 0.441 |
| LSG1 | FAM43A | ENSP00000265245 | ENSP00000371397 | Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable). | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | 0.578 |
| LSG1 | TMEM44 | ENSP00000265245 | ENSP00000376227 | Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable). | Transmembrane protein 44. | 0.549 |
| PPP2R5A | FAM43A | ENSP00000261461 | ENSP00000371397 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | 0.591 |
| PPP2R5A | PPP2R5B | ENSP00000261461 | ENSP00000164133 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. | 0.848 |
| PPP2R5A | PPP2R5C | ENSP00000261461 | ENSP00000412324 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. | 0.969 |
| PPP2R5B | FAM43A | ENSP00000164133 | ENSP00000371397 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | 0.610 |
| PPP2R5B | PPP2R5A | ENSP00000164133 | ENSP00000261461 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.848 |
| PPP2R5B | PPP2R5C | ENSP00000164133 | ENSP00000412324 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. | 0.859 |
| PPP2R5C | FAM43A | ENSP00000412324 | ENSP00000371397 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | 0.465 |