STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GAB4GRB2 associated binding protein family member 4; Belongs to the GAB family. (574 aa)    
Predicted Functional Partners:
LRRC74B
Leucine-rich repeat-containing protein 74B; Leucine rich repeat containing 74B.
      
 0.547
RIMBP3C
RIMS-binding protein 3C; Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development.
      
 0.529
GRB2
Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family.
    
 
 0.528
CCT8L2
T-complex protein 1 subunit theta-like 2; Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis; Belongs to the TCP-1 chaperonin family.
   
  
 0.520
C2CD4D
C2 calcium-dependent domain-containing protein 4D; C2 calcium dependent domain containing 4D.
      
 0.479
OR2B11
Olfactory receptor 2B11; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.433
ZSCAN30
Zinc finger and SCAN domain-containing protein 30; May be involved in transcriptional regulation.
      
 0.431
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.