STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMCO2Single-pass membrane protein with coiled-coil domains 2. (343 aa)    
Predicted Functional Partners:
PPFIBP1
Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Belongs to the liprin family. Liprin-beta subfamily.
      
 0.691
ARNTL2
Aryl hydrocarbon receptor nuclear translocator-like protein 2; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressur [...]
   
  
 0.656
CDRT15
CMT1A duplicated region transcript 15.
      
 0.600
STK38L
Serine/threonine-protein kinase 38-like; Involved in the regulation of structural processes in differentiating and mature neuronal cells; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
      
 0.578
CXorf65
Uncharacterized protein CXorf65; Chromosome X open reading frame 65.
      
 0.513
CDRT4
CMT1A duplicated region transcript 4.
      
 0.507
TMEM167A
Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.
      
 0.474
CCDC90B
Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B.
      
 0.471
TVP23B
Trans-golgi network vesicle protein 23 homolog B; Belongs to the TVP23 family.
      
 0.448
TVP23C
Trans-golgi network vesicle protein 23 homolog C; Belongs to the TVP23 family.
      
 0.447
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.