ERI3 protein (human) - STRING interaction network

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Score

ERI3

ERI1 exoribonuclease family member 3. (337 aa)

Predicted Functional Partners:

PRNP

0.798

SYN3

0.694

SYN2

0.660

DUS3L

0.643

SYN1

0.573

GRB2

0.523

TRAPPC1

0.517

RNF220

0.512

TRAPPC4

0.500

CCDC24

0.497

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC24	ERI3	ENSP00000361392	ENSP00000361331	Coiled-coil domain containing 24.	ERI1 exoribonuclease family member 3.	0.497
CCDC24	RNF220	ENSP00000361392	ENSP00000347548	Coiled-coil domain containing 24.	E3 ubiquitin-protein ligase RNF220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 promoting Wnt signaling.	0.472
DUS3L	ERI3	ENSP00000311977	ENSP00000361331	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus3 subfamily.	ERI1 exoribonuclease family member 3.	0.643
ERI3	CCDC24	ENSP00000361331	ENSP00000361392	ERI1 exoribonuclease family member 3.	Coiled-coil domain containing 24.	0.497
ERI3	DUS3L	ENSP00000361331	ENSP00000311977	ERI1 exoribonuclease family member 3.	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus3 subfamily.	0.643
ERI3	GRB2	ENSP00000361331	ENSP00000376345	ERI1 exoribonuclease family member 3.	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family.	0.523
ERI3	PRNP	ENSP00000361331	ENSP00000399376	ERI1 exoribonuclease family member 3.	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]	0.798
ERI3	RNF220	ENSP00000361331	ENSP00000347548	ERI1 exoribonuclease family member 3.	E3 ubiquitin-protein ligase RNF220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 promoting Wnt signaling.	0.512
ERI3	SYN1	ENSP00000361331	ENSP00000295987	ERI1 exoribonuclease family member 3.	Synapsin-1; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.	0.573
ERI3	SYN2	ENSP00000361331	ENSP00000480050	ERI1 exoribonuclease family member 3.	Synapsin-2; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity); Belongs to the synapsin family.	0.660
ERI3	SYN3	ENSP00000361331	ENSP00000351614	ERI1 exoribonuclease family member 3.	Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis.	0.694
ERI3	TRAPPC1	ENSP00000361331	ENSP00000302783	ERI1 exoribonuclease family member 3.	Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET5 subfamily.	0.517
ERI3	TRAPPC4	ENSP00000361331	ENSP00000436005	ERI1 exoribonuclease family member 3.	Trafficking protein particle complex subunit 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi.	0.500
GRB2	ERI3	ENSP00000376345	ENSP00000361331	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family.	ERI1 exoribonuclease family member 3.	0.523
GRB2	PRNP	ENSP00000376345	ENSP00000399376	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family.	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]	0.859
GRB2	SYN1	ENSP00000376345	ENSP00000295987	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family.	Synapsin-1; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.	0.830
PRNP	ERI3	ENSP00000399376	ENSP00000361331	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]	ERI1 exoribonuclease family member 3.	0.798
PRNP	GRB2	ENSP00000399376	ENSP00000376345	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family.	0.859
PRNP	SYN1	ENSP00000399376	ENSP00000295987	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]	Synapsin-1; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.	0.675
PRNP	SYN3	ENSP00000399376	ENSP00000351614	Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]	Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis.	0.412