FAM163B protein (human) - STRING interaction network

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FAM163B

Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family. (166 aa)

Predicted Functional Partners:

ZC2HC1B

0.636

PPP3CB

0.597

SEC22C

0.578

ZDHHC22

0.564

CACFD1

0.553

UEVLD

0.526

NETO1

0.525

PPP3CA

0.515

ALS2CL

0.510

GPSM1

0.503

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALS2CL	FAM163B	ENSP00000313670	ENSP00000501259	ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	0.510
ALS2CL	UEVLD	ENSP00000313670	ENSP00000379500	ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.	Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination. In the N-terminal section; belongs to the ubiquitin- conjugating enzyme family. UEV subfamily.	0.434
CACFD1	FAM163B	ENSP00000440832	ENSP00000501259	Calcium channel flower domain containing 1.	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	0.553
CACFD1	GPSM1	ENSP00000440832	ENSP00000392828	Calcium channel flower domain containing 1.	G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein- coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Belongs to the GPSM family.	0.480
FAM163B	ALS2CL	ENSP00000501259	ENSP00000313670	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.	0.510
FAM163B	CACFD1	ENSP00000501259	ENSP00000440832	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	Calcium channel flower domain containing 1.	0.553
FAM163B	GPSM1	ENSP00000501259	ENSP00000392828	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein- coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Belongs to the GPSM family.	0.503
FAM163B	NETO1	ENSP00000501259	ENSP00000313088	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	Neuropilin and tolloid-like protein 1; Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A- containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).	0.525
FAM163B	PPP3CA	ENSP00000501259	ENSP00000378323	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylat [...]	0.515
FAM163B	PPP3CB	ENSP00000501259	ENSP00000378306	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32 ; Belongs to the PPP phosphatase family. PP-2B subfamily.	0.597
FAM163B	SEC22C	ENSP00000501259	ENSP00000264454	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	Vesicle-trafficking protein SEC22c; May be involved in vesicle transport between the ER and the Golgi complex.	0.578
FAM163B	UEVLD	ENSP00000501259	ENSP00000379500	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination. In the N-terminal section; belongs to the ubiquitin- conjugating enzyme family. UEV subfamily.	0.526
FAM163B	ZC2HC1B	ENSP00000501259	ENSP00000237275	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	Zinc finger C2HC-type containing 1B; Belongs to the ZC2HC1 family.	0.636
FAM163B	ZDHHC22	ENSP00000501259	ENSP00000318222	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	Palmitoyltransferase ZDHHC22; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. Might also mediate palmitoylation of CNN3 (By similarity).	0.564
GPSM1	CACFD1	ENSP00000392828	ENSP00000440832	G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein- coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Belongs to the GPSM family.	Calcium channel flower domain containing 1.	0.480
GPSM1	FAM163B	ENSP00000392828	ENSP00000501259	G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein- coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Belongs to the GPSM family.	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	0.503
NETO1	FAM163B	ENSP00000313088	ENSP00000501259	Neuropilin and tolloid-like protein 1; Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A- containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	0.525
PPP3CA	FAM163B	ENSP00000378323	ENSP00000501259	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylat [...]	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	0.515
PPP3CA	PPP3CB	ENSP00000378323	ENSP00000378306	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylat [...]	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32 ; Belongs to the PPP phosphatase family. PP-2B subfamily.	0.999
PPP3CB	FAM163B	ENSP00000378306	ENSP00000501259	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32 ; Belongs to the PPP phosphatase family. PP-2B subfamily.	Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.	0.597