| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C19orf85 | FAM181B | ENSP00000490220 | ENSP00000365295 | Uncharacterized protein C19orf85; Chromosome 19 open reading frame 85. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.442 |
| CHST3 | CNBD2 | ENSP00000362207 | ENSP00000340954 | Carbohydrate sulfotransferase 3; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of [...] | Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm. | 0.458 |
| CHST3 | FAM181B | ENSP00000362207 | ENSP00000365295 | Carbohydrate sulfotransferase 3; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of [...] | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.480 |
| CNBD2 | CHST3 | ENSP00000340954 | ENSP00000362207 | Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm. | Carbohydrate sulfotransferase 3; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of [...] | 0.458 |
| CNBD2 | FAM181B | ENSP00000340954 | ENSP00000365295 | Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.472 |
| CNBD2 | TMIE | ENSP00000340954 | ENSP00000494576 | Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm. | Transmembrane inner ear expressed protein; Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain. | 0.481 |
| DDIAS | FAM181B | ENSP00000435421 | ENSP00000365295 | DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.592 |
| DDIAS | ZNF536 | ENSP00000435421 | ENSP00000347730 | DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival. | Zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.400 |
| FAM181B | C19orf85 | ENSP00000365295 | ENSP00000490220 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Uncharacterized protein C19orf85; Chromosome 19 open reading frame 85. | 0.442 |
| FAM181B | CHST3 | ENSP00000365295 | ENSP00000362207 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Carbohydrate sulfotransferase 3; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of [...] | 0.480 |
| FAM181B | CNBD2 | ENSP00000365295 | ENSP00000340954 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm. | 0.472 |
| FAM181B | DDIAS | ENSP00000365295 | ENSP00000435421 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival. | 0.592 |
| FAM181B | PRCP | ENSP00000365295 | ENSP00000377055 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Lysosomal Pro-X carboxypeptidase; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. | 0.579 |
| FAM181B | TCP11L1 | ENSP00000365295 | ENSP00000335595 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | T-complex protein 11-like protein 1; T-complex 11 like 1. | 0.412 |
| FAM181B | TEAD4 | ENSP00000365295 | ENSP00000352926 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] | 0.906 |
| FAM181B | TMEM101 | ENSP00000365295 | ENSP00000468025 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Transmembrane protein 101; May activate NF-kappa-B signaling pathways. | 0.443 |
| FAM181B | TMIE | ENSP00000365295 | ENSP00000494576 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Transmembrane inner ear expressed protein; Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain. | 0.489 |
| FAM181B | ZNF536 | ENSP00000365295 | ENSP00000347730 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | Zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.602 |
| PRCP | FAM181B | ENSP00000377055 | ENSP00000365295 | Lysosomal Pro-X carboxypeptidase; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.579 |
| TCP11L1 | FAM181B | ENSP00000335595 | ENSP00000365295 | T-complex protein 11-like protein 1; T-complex 11 like 1. | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family. | 0.412 |
