FAM184B protein (human) - STRING interaction network

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FAM184B

Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. (1060 aa)

Predicted Functional Partners:

NCAPG

0.773

DCAF16

0.753

LCORL

0.751

MED28

0.721

NPM1

0.642

PACRGL

0.639

EEF1B2

0.566

FAM13A

0.555

MEPE

0.535

DNAJC27

0.517

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCAF16	FAM184B	ENSP00000371682	ENSP00000265018	DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	0.753
DCAF16	LCORL	ENSP00000371682	ENSP00000371661	DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.	Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity).	0.675
DCAF16	MED28	ENSP00000371682	ENSP00000237380	DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.	Mediator of RNA polymerase II transcription subunit 28; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex [...]	0.636
DCAF16	NCAPG	ENSP00000371682	ENSP00000251496	DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.	Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.	0.721
DCAF16	PACRGL	ENSP00000371682	ENSP00000423881	DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.	PACRG-like protein; Parkin coregulated like.	0.404
DNAJC27	FAM184B	ENSP00000264711	ENSP00000265018	DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	0.517
EEF1B2	FAM184B	ENSP00000376055	ENSP00000265018	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	0.566
EEF1B2	NPM1	ENSP00000376055	ENSP00000296930	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.	Nucleophosmin; Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. M [...]	0.921
FAM13A	FAM184B	ENSP00000264344	ENSP00000265018	Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family.	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	0.555
FAM184B	DCAF16	ENSP00000265018	ENSP00000371682	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.	0.753
FAM184B	DNAJC27	ENSP00000265018	ENSP00000264711	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.	0.517
FAM184B	EEF1B2	ENSP00000265018	ENSP00000376055	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.	0.566
FAM184B	FAM13A	ENSP00000265018	ENSP00000264344	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family.	0.555
FAM184B	LCORL	ENSP00000265018	ENSP00000371661	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity).	0.751
FAM184B	MED28	ENSP00000265018	ENSP00000237380	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	Mediator of RNA polymerase II transcription subunit 28; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex [...]	0.721
FAM184B	MEPE	ENSP00000265018	ENSP00000378534	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation. Belongs to the PF07175/osteoregulin family.	0.535
FAM184B	NCAPG	ENSP00000265018	ENSP00000251496	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.	0.773
FAM184B	NPM1	ENSP00000265018	ENSP00000296930	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	Nucleophosmin; Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. M [...]	0.642
FAM184B	PACRGL	ENSP00000265018	ENSP00000423881	Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.	PACRG-like protein; Parkin coregulated like.	0.639
LCORL	DCAF16	ENSP00000371661	ENSP00000371682	Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity).	DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.	0.675