Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FAM209AProtein FAM209A; Family with sequence similarity 209 member A. (171 aa)    
Predicted Functional Partners:
FAM209B
Protein FAM209B; Family with sequence similarity 209 member B.
   
  
0.871
UBASH3B
Ubiquitin-associated and SH3 domain-containing protein B; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
    
   0.773
TMCO5A
Transmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family.
   
  
 0.705
SPEM1
Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis.
   
  
 0.685
CAPZA3
F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).
   
  
 0.653
C9orf131
Uncharacterized protein C9orf131; Chromosome 9 open reading frame 131.
      
 0.649
FAM166A
Protein FAM166A; Family with sequence similarity 166 member A.
   
    0.630
C9orf43
Uncharacterized protein C9orf43; Chromosome 9 open reading frame 43.
      
 0.626
TEKT5
Tektin-5; May be a structural component of the sperm flagellum.
   
  
 0.622
TMCO2
Transmembrane and coiled-coil domains 2.
   
  
 0.604
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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