FAM3A protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

FAM3A

Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family. (244 aa)

Predicted Functional Partners:

SNX15

0.588

C3orf18

0.485

CDC123

0.476

RNF149

0.476

UNC45A

0.448

B3GNT2

0.408

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B3GNT2	FAM3A	ENSP00000305595	ENSP00000320521	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors. Probably constitutes the main polylactosamine synthase. Belongs to the glycosyltransferase 31 family.	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	0.408
C3orf18	FAM3A	ENSP00000349732	ENSP00000320521	Uncharacterized protein C3orf18; Chromosome 3 open reading frame 18.	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	0.485
C3orf18	UNC45A	ENSP00000349732	ENSP00000407487	Uncharacterized protein C3orf18; Chromosome 3 open reading frame 18.	Protein unc-45 homolog A; Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).	0.451
CDC123	FAM3A	ENSP00000281141	ENSP00000320521	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	0.476
CDC123	UNC45A	ENSP00000281141	ENSP00000407487	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	Protein unc-45 homolog A; Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).	0.512
FAM3A	B3GNT2	ENSP00000320521	ENSP00000305595	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors. Probably constitutes the main polylactosamine synthase. Belongs to the glycosyltransferase 31 family.	0.408
FAM3A	C3orf18	ENSP00000320521	ENSP00000349732	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	Uncharacterized protein C3orf18; Chromosome 3 open reading frame 18.	0.485
FAM3A	CDC123	ENSP00000320521	ENSP00000281141	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	0.476
FAM3A	RNF149	ENSP00000320521	ENSP00000295317	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	E3 ubiquitin-protein ligase RNF149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.	0.476
FAM3A	SNX15	ENSP00000320521	ENSP00000366452	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.	0.588
FAM3A	UNC45A	ENSP00000320521	ENSP00000407487	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	Protein unc-45 homolog A; Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).	0.448
RNF149	FAM3A	ENSP00000295317	ENSP00000320521	E3 ubiquitin-protein ligase RNF149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	0.476
SNX15	FAM3A	ENSP00000366452	ENSP00000320521	Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	0.588
UNC45A	C3orf18	ENSP00000407487	ENSP00000349732	Protein unc-45 homolog A; Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).	Uncharacterized protein C3orf18; Chromosome 3 open reading frame 18.	0.451
UNC45A	CDC123	ENSP00000407487	ENSP00000281141	Protein unc-45 homolog A; Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).	Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.	0.512
UNC45A	FAM3A	ENSP00000407487	ENSP00000320521	Protein unc-45 homolog A; Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.	0.448