Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FRRS1LDOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway. (344 aa)    
Predicted Functional Partners:
ABITRAM
Protein Abitram; Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons.
      
 0.882
MRPL46
Mitochondrial ribosomal protein L46; Belongs to the mitochondrion-specific ribosomal protein mL46 family.
   
 
 0.849
MRPL3
Mitochondrial ribosomal protein L3.
   
 
 0.844
MRPL23
Mitochondrial ribosomal protein L23.
   
 
 0.840
MRPL13
Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family.
   
 
 0.822
MRPL41
39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
   
 
 0.813
MRPL4
Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family.
   
 
 0.811
MRPL11
Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family.
   
 
 0.811
MRPL19
Mitochondrial ribosomal protein L19.
   
 
 0.807
MRPS35
Mitochondrial ribosomal protein S35.
   
 
 0.803
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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