Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
GPR148Probable G-protein coupled receptor 148; Orphan receptor. (347 aa)    
Predicted Functional Partners:
GPR152
Probable G-protein coupled receptor 152; Orphan receptor.
   
  
 0.568
AMER3
APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity).
 
    
 0.545
GPR139
Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
      
 0.505
EXOC3L2
Exocyst complex component 3 like 2; Belongs to the SEC6 family.
    
   0.500
GPR162
Probable G-protein coupled receptor 162; Orphan receptor.
      
 0.498
GPR141
Probable G-protein coupled receptor 141; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.491
OR4D10
Olfactory receptor 4D10; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
    0.483
GPR146
Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.464
GPR150
Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.457
GPR142
Probable G-protein coupled receptor 142; Orphan receptor.
   
  
 0.453
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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