| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANTXR2 | HS1BP3 | ENSP00000306185 | ENSP00000305193 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix; Belongs to the ATR family. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.490 |
| CHP1 | HS1BP3 | ENSP00000335632 | ENSP00000305193 | Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.761 |
| CORO1B | HS1BP3 | ENSP00000340211 | ENSP00000305193 | Coronin-1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.560 |
| CORO1B | IFI30 | ENSP00000340211 | ENSP00000384886 | Coronin-1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). | Gamma-interferon-inducible lysosomal thiol reductase; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I- restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). | 0.535 |
| HS1BP3 | ANTXR2 | ENSP00000305193 | ENSP00000306185 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix; Belongs to the ATR family. | 0.490 |
| HS1BP3 | CHP1 | ENSP00000305193 | ENSP00000335632 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] | 0.761 |
| HS1BP3 | CORO1B | ENSP00000305193 | ENSP00000340211 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Coronin-1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). | 0.560 |
| HS1BP3 | IFI30 | ENSP00000305193 | ENSP00000384886 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Gamma-interferon-inducible lysosomal thiol reductase; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I- restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). | 0.811 |
| HS1BP3 | LDAH | ENSP00000305193 | ENSP00000237822 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages; Belongs to the AB hydrolase superfamily. LDAH family. | 0.712 |
| HS1BP3 | TADA2B | ENSP00000305193 | ENSP00000308022 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Transcriptional adapter 2-beta; Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. | 0.535 |
| HS1BP3 | TCHH | ENSP00000305193 | ENSP00000480484 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. | 0.534 |
| HS1BP3 | TMED3 | ENSP00000305193 | ENSP00000299705 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Transmembrane emp24 domain-containing protein 3; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. Belongs to the EMP24/GP25L family. | 0.703 |
| HS1BP3 | TOR2A | ENSP00000305193 | ENSP00000362381 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Torsin-2A; Torsin family 2 member A; Belongs to the ClpA/ClpB family. Torsin subfamily. | 0.550 |
| HS1BP3 | USP5 | ENSP00000305193 | ENSP00000229268 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys- 48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. | 0.518 |
| IFI30 | CORO1B | ENSP00000384886 | ENSP00000340211 | Gamma-interferon-inducible lysosomal thiol reductase; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I- restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). | Coronin-1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). | 0.535 |
| IFI30 | HS1BP3 | ENSP00000384886 | ENSP00000305193 | Gamma-interferon-inducible lysosomal thiol reductase; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I- restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.811 |
| LDAH | HS1BP3 | ENSP00000237822 | ENSP00000305193 | Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages; Belongs to the AB hydrolase superfamily. LDAH family. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.712 |
| TADA2B | HS1BP3 | ENSP00000308022 | ENSP00000305193 | Transcriptional adapter 2-beta; Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.535 |
| TCHH | HS1BP3 | ENSP00000480484 | ENSP00000305193 | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.534 |
| TMED3 | HS1BP3 | ENSP00000299705 | ENSP00000305193 | Transmembrane emp24 domain-containing protein 3; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. Belongs to the EMP24/GP25L family. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.703 |
