HSPB2 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

HSPB2

Heat shock protein beta-2; May regulate the kinase DMPK. (182 aa)

Predicted Functional Partners:

CRYAB

0.997

HSPB3

0.974

MAPK14

0.963

MAPK11

0.960

MAPK12

0.956

MAPK13

0.955

HSPA4

0.925

MYOZ2

0.903

HSPB8

0.865

SGCG

0.859

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRYAB	HSPA4	ENSP00000433560	ENSP00000302961	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	0.683
CRYAB	HSPB2	ENSP00000433560	ENSP00000302476	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein beta-2; May regulate the kinase DMPK.	0.997
CRYAB	HSPB8	ENSP00000433560	ENSP00000281938	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family.	0.813
CRYAB	MYOZ2	ENSP00000433560	ENSP00000306997	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Myozenin-2; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.	0.513
HSPA4	CRYAB	ENSP00000302961	ENSP00000433560	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.683
HSPA4	HSPB2	ENSP00000302961	ENSP00000302476	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Heat shock protein beta-2; May regulate the kinase DMPK.	0.925
HSPA4	HSPB3	ENSP00000302961	ENSP00000303394	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Heat shock protein beta-3; Inhibitor of actin polymerization.	0.919
HSPA4	HSPB8	ENSP00000302961	ENSP00000281938	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family.	0.717
HSPA4	MAPK11	ENSP00000302961	ENSP00000333685	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Mitogen-activated protein kinase 11; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MA [...]	0.419
HSPA4	MAPK13	ENSP00000302961	ENSP00000211287	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...]	0.419
HSPA4	MAPK14	ENSP00000302961	ENSP00000229795	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...]	0.437
HSPB2	CRYAB	ENSP00000302476	ENSP00000433560	Heat shock protein beta-2; May regulate the kinase DMPK.	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.997
HSPB2	HSPA4	ENSP00000302476	ENSP00000302961	Heat shock protein beta-2; May regulate the kinase DMPK.	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	0.925
HSPB2	HSPB3	ENSP00000302476	ENSP00000303394	Heat shock protein beta-2; May regulate the kinase DMPK.	Heat shock protein beta-3; Inhibitor of actin polymerization.	0.974
HSPB2	HSPB8	ENSP00000302476	ENSP00000281938	Heat shock protein beta-2; May regulate the kinase DMPK.	Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family.	0.865
HSPB2	MAPK11	ENSP00000302476	ENSP00000333685	Heat shock protein beta-2; May regulate the kinase DMPK.	Mitogen-activated protein kinase 11; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MA [...]	0.960
HSPB2	MAPK12	ENSP00000302476	ENSP00000215659	Heat shock protein beta-2; May regulate the kinase DMPK.	Mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstre [...]	0.956
HSPB2	MAPK13	ENSP00000302476	ENSP00000211287	Heat shock protein beta-2; May regulate the kinase DMPK.	Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...]	0.955
HSPB2	MAPK14	ENSP00000302476	ENSP00000229795	Heat shock protein beta-2; May regulate the kinase DMPK.	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...]	0.963
HSPB2	MYOZ2	ENSP00000302476	ENSP00000306997	Heat shock protein beta-2; May regulate the kinase DMPK.	Myozenin-2; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.	0.903