| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CFAP54 | DNAH3 | ENSP00000431759 | ENSP00000261383 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family. | 0.584 |
| CFAP54 | HYDIN | ENSP00000431759 | ENSP00000377197 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | Hydrocephalus-inducing protein homolog; Required for ciliary motility. | 0.864 |
| CFAP54 | SPAG17 | ENSP00000431759 | ENSP00000337804 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.800 |
| DNAH3 | CFAP54 | ENSP00000261383 | ENSP00000431759 | Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family. | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella. | 0.584 |
| DNAH3 | HYDIN | ENSP00000261383 | ENSP00000377197 | Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family. | Hydrocephalus-inducing protein homolog; Required for ciliary motility. | 0.863 |
| DNAH3 | SPAG17 | ENSP00000261383 | ENSP00000337804 | Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.543 |
| DRD5 | GPRIN2 | ENSP00000306129 | ENSP00000363436 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | 0.839 |
| DRD5 | HYDIN | ENSP00000306129 | ENSP00000377197 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | Hydrocephalus-inducing protein homolog; Required for ciliary motility. | 0.834 |
| DRD5 | NBPF1 | ENSP00000306129 | ENSP00000474456 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | Neuroblastoma breakpoint family member 1; NBPF member 1; Belongs to the NBPF family. | 0.822 |
| DRD5 | NPEPPS | ENSP00000306129 | ENSP00000320324 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. | 0.821 |
| DRD5 | SRGAP2 | ENSP00000306129 | ENSP00000459615 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.760 |
| DRD5 | SRGAP3 | ENSP00000306129 | ENSP00000373347 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. | 0.768 |
| DRD5 | UGT2B17 | ENSP00000306129 | ENSP00000320401 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4- methylumbelliferone > dihydrotestosterone (DHT) > androstane-3- alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT). | 0.824 |
| GPRIN2 | DRD5 | ENSP00000363436 | ENSP00000306129 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | 0.839 |
| GPRIN2 | HYDIN | ENSP00000363436 | ENSP00000377197 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | Hydrocephalus-inducing protein homolog; Required for ciliary motility. | 0.866 |
| GPRIN2 | NBPF1 | ENSP00000363436 | ENSP00000474456 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | Neuroblastoma breakpoint family member 1; NBPF member 1; Belongs to the NBPF family. | 0.839 |
| GPRIN2 | NPEPPS | ENSP00000363436 | ENSP00000320324 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. | 0.833 |
| GPRIN2 | SRGAP2 | ENSP00000363436 | ENSP00000459615 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.855 |
| GPRIN2 | SRGAP3 | ENSP00000363436 | ENSP00000373347 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. | 0.848 |
| GPRIN2 | UGT2B17 | ENSP00000363436 | ENSP00000320401 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth. | UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4- methylumbelliferone > dihydrotestosterone (DHT) > androstane-3- alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT). | 0.844 |
