Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ICA1LIslet cell autoantigen 1 like. (482 aa)    
Predicted Functional Partners:
PICK1
PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...]
    
 
 0.819
NBEAL1
Neurobeachin-like protein 1; Neurobeachin like 1; Belongs to the WD repeat neurobeachin family.
   
  
 0.723
FAM117B
Protein FAM117B; Family with sequence similarity 117 member B.
   
  
 0.690
CYP20A1
Cytochrome P450 family 20 subfamily A member 1.
   
 
 0.568
WDR12
Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
      
 0.567
ABI3BP
Target of Nesh-SH3; ABI family member 3 binding protein.
   
  
 0.553
GK5
Glycerol kinase 5.
   
  
 0.539
GFAP
Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
   
   0.533
SNX32
Sorting nexin-32; May be involved in several stages of intracellular trafficking.
   
  
 0.517
TOM1L2
TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling.
   
  
 0.506
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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