Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
IGFL1Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. (110 aa)    
Predicted Functional Partners:
IGFLR1
IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.
    
 
 0.848
NPTX2
Neuronal pentraxin-2; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).
    
   0.642
OR1J4
Olfactory receptor 1J4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
    0.578
STH
Saitohin.
   
    0.556
OR8B12
Olfactory receptor 8B12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
    0.536
TNP1
Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Belongs to the nuclear transition protein 1 family.
   
    0.530
TMEM225
Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.
   
    0.530
PRCD
Photoreceptor disk component PRCD; Involved in vision; Belongs to the PRCD family.
   
    0.499
SFTA2
Surfactant-associated protein 2; Putative surfactant protein.
   
    0.488
OR56A5
Olfactory receptor 56A5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
    0.486
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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