Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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KCNK6Potassium channel subfamily K member 6; Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (313 aa)    
Predicted Functional Partners:
KRT76
Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification. Belongs to the intermediate filament family.
      
 0.974
KCNA3
Potassium voltage-gated channel subfamily A member 3; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
      
 0.721
KCNK18
Potassium channel subfamily K member 18; Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3- 3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring [...]
     
0.627
KCNK7
Potassium channel subfamily K member 7; Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  
 
0.627
KCNK13
Potassium channel subfamily K member 13; Potassium channel displaying weak inward rectification in symmetrical K(+) solution; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
 
0.622
KCNK15
Potassium channel subfamily K member 15; Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.
   
 
0.622
KCNK3
Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
 
0.616
KCNK12
Potassium channel subfamily K member 12; Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).
   
 
0.609
KCNK4
Potassium channel subfamily K member 4; Voltage-insensitive potassium channel. Channel opening is triggered by mechanical forces that deform the membrane. Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a ro [...]
  
  
0.608
KCNK9
Potassium channel subfamily K member 9; pH-dependent, voltage-insensitive, background potassium channel protein.
   
 
0.604
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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