| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AAR2 | CD2BP2 | ENSP00000363043 | ENSP00000304903 | Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Belongs to the AAR2 family. | CD2 antigen cytoplasmic tail-binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. | 0.998 |
| AAR2 | KLHL36 | ENSP00000363043 | ENSP00000456743 | Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Belongs to the AAR2 family. | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.542 |
| APEX1 | KLHL36 | ENSP00000216714 | ENSP00000456743 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.732 |
| CD2BP2 | AAR2 | ENSP00000304903 | ENSP00000363043 | CD2 antigen cytoplasmic tail-binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. | Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Belongs to the AAR2 family. | 0.998 |
| CD2BP2 | KLHL36 | ENSP00000304903 | ENSP00000456743 | CD2 antigen cytoplasmic tail-binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.565 |
| CUL3 | KLHL36 | ENSP00000264414 | ENSP00000456743 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.940 |
| CXorf56 | KLHL36 | ENSP00000441786 | ENSP00000456743 | UPF0428 protein CXorf56; Chromosome X open reading frame 56. | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.672 |
| DCLK2 | KLHL36 | ENSP00000303887 | ENSP00000456743 | Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.571 |
| DCLK2 | SLC15A5 | ENSP00000303887 | ENSP00000340402 | Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). | Solute carrier family 15 member 5; Proton oligopeptide cotransporter. | 0.442 |
| FAM92B | KIAA0513 | ENSP00000443411 | ENSP00000457408 | Protein FAM92B; May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis. | Uncharacterized protein KIAA0513; KIAA0513. | 0.586 |
| FAM92B | KLHL36 | ENSP00000443411 | ENSP00000456743 | Protein FAM92B; May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis. | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.607 |
| KIAA0513 | FAM92B | ENSP00000457408 | ENSP00000443411 | Uncharacterized protein KIAA0513; KIAA0513. | Protein FAM92B; May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis. | 0.586 |
| KIAA0513 | KLHL36 | ENSP00000457408 | ENSP00000456743 | Uncharacterized protein KIAA0513; KIAA0513. | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.645 |
| KLHL36 | AAR2 | ENSP00000456743 | ENSP00000363043 | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Belongs to the AAR2 family. | 0.542 |
| KLHL36 | APEX1 | ENSP00000456743 | ENSP00000216714 | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | 0.732 |
| KLHL36 | CD2BP2 | ENSP00000456743 | ENSP00000304903 | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | CD2 antigen cytoplasmic tail-binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. | 0.565 |
| KLHL36 | CUL3 | ENSP00000456743 | ENSP00000264414 | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | 0.940 |
| KLHL36 | CXorf56 | ENSP00000456743 | ENSP00000441786 | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | UPF0428 protein CXorf56; Chromosome X open reading frame 56. | 0.672 |
| KLHL36 | DCLK2 | ENSP00000456743 | ENSP00000303887 | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). | 0.571 |
| KLHL36 | FAM92B | ENSP00000456743 | ENSP00000443411 | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | Protein FAM92B; May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis. | 0.607 |
