Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KRT33AKeratin, type I cuticular Ha3-I; Keratin 33A; Belongs to the intermediate filament family. (404 aa)    
Predicted Functional Partners:
KRT34
Keratin, type I cuticular Ha4; Keratin 34.
  
0.982
KRT31
Keratin, type I cuticular Ha1; Keratin 31.
  
0.941
KRT33B
Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family.
  
0.937
KRT40
Keratin, type I cytoskeletal 40; May play a role in late hair differentiation; Belongs to the intermediate filament family.
  
 
0.929
KRT83
Keratin, type II cuticular Hb3; Keratin 83; Belongs to the intermediate filament family.
  
 
0.775
KRT86
Keratin, type II cuticular Hb6.
  
 
0.767
KRT32
Keratin, type I cuticular Ha2; Keratin 32; Belongs to the intermediate filament family.
  
 
0.755
KRT85
Keratin, type II cuticular Hb5; Keratin 85; Belongs to the intermediate filament family.
  
 
0.754
KRT82
Keratin, type II cuticular Hb2; Keratin 82; Belongs to the intermediate filament family.
  
 
0.737
KRT35
Keratin, type I cuticular Ha5; Keratin 35; Belongs to the intermediate filament family.
  
 
0.692
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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