KRTAP4-12 protein (human) - STRING interaction network

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Score

KRTAP4-12

Keratin associated protein 4-12. (201 aa)

Predicted Functional Partners:

SMCP

0.901

LCE1E

0.844

LCE5A

0.839

LCE1A

0.839

LCE2C

0.839

KRTAP3-1

0.836

CRCT1

0.828

KRTAP2-1

0.828

LCE1B

0.793

IGSF8

0.777

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRCT1	KRTAP4-12	ENSP00000357779	ENSP00000377582	Cysteine rich C-terminal 1.	Keratin associated protein 4-12.	0.828
CRCT1	LCE2C	ENSP00000357779	ENSP00000357772	Cysteine rich C-terminal 1.	Late cornified envelope protein 2C; Precursors of the cornified envelope of the stratum.	0.595
IGSF8	KRTAP4-12	ENSP00000357065	ENSP00000377582	Immunoglobulin superfamily member 8; May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the [...]	Keratin associated protein 4-12.	0.777
KRTAP2-1	KRTAP3-1	ENSP00000375238	ENSP00000375430	Keratin-associated protein 2-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity); Belongs to the KRTAP type 2 family.	Keratin-associated protein 3-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	0.886
KRTAP2-1	KRTAP4-12	ENSP00000375238	ENSP00000377582	Keratin-associated protein 2-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity); Belongs to the KRTAP type 2 family.	Keratin associated protein 4-12.	0.828
KRTAP3-1	KRTAP2-1	ENSP00000375430	ENSP00000375238	Keratin-associated protein 3-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	Keratin-associated protein 2-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity); Belongs to the KRTAP type 2 family.	0.886
KRTAP3-1	KRTAP4-12	ENSP00000375430	ENSP00000377582	Keratin-associated protein 3-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	Keratin associated protein 4-12.	0.836
KRTAP4-12	CRCT1	ENSP00000377582	ENSP00000357779	Keratin associated protein 4-12.	Cysteine rich C-terminal 1.	0.828
KRTAP4-12	IGSF8	ENSP00000377582	ENSP00000357065	Keratin associated protein 4-12.	Immunoglobulin superfamily member 8; May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the [...]	0.777
KRTAP4-12	KRTAP2-1	ENSP00000377582	ENSP00000375238	Keratin associated protein 4-12.	Keratin-associated protein 2-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity); Belongs to the KRTAP type 2 family.	0.828
KRTAP4-12	KRTAP3-1	ENSP00000377582	ENSP00000375430	Keratin associated protein 4-12.	Keratin-associated protein 3-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.	0.836
KRTAP4-12	LCE1A	ENSP00000377582	ENSP00000334869	Keratin associated protein 4-12.	Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum.	0.839
KRTAP4-12	LCE1B	ENSP00000377582	ENSP00000353203	Keratin associated protein 4-12.	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.	0.793
KRTAP4-12	LCE1E	ENSP00000377582	ENSP00000357759	Keratin associated protein 4-12.	Late cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum.	0.844
KRTAP4-12	LCE2C	ENSP00000377582	ENSP00000357772	Keratin associated protein 4-12.	Late cornified envelope protein 2C; Precursors of the cornified envelope of the stratum.	0.839
KRTAP4-12	LCE5A	ENSP00000377582	ENSP00000333952	Keratin associated protein 4-12.	Late cornified envelope protein 5A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	0.839
KRTAP4-12	SMCP	ENSP00000377582	ENSP00000357754	Keratin associated protein 4-12.	Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).	0.901
LCE1A	KRTAP4-12	ENSP00000334869	ENSP00000377582	Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum.	Keratin associated protein 4-12.	0.839
LCE1A	LCE1B	ENSP00000334869	ENSP00000353203	Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum.	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.	0.977
LCE1A	LCE1E	ENSP00000334869	ENSP00000357759	Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum.	Late cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum.	0.994