Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LCE3BLate cornified envelope protein 3B; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. (95 aa)    
Predicted Functional Partners:
LCE1D
Late cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum.
   
 0.939
LCE1E
Late cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum.
    
 0.933
LCE1A
Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum.
   
 0.930
LCE1C
Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.
    
 0.854
LCE1B
Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.
    
 0.852
KRTAP5-9
Keratin associated protein 5-9.
    
   0.839
LCE2C
Late cornified envelope protein 2C; Precursors of the cornified envelope of the stratum.
   
 0.833
LOR
Loricrin; Major keratinocyte cell envelope protein.
     
 0.831
IVL
Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family.
     
 0.831
KRTAP5-4
Keratin associated protein 5-4.
    
   0.819
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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