Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
LCN8Epididymal-specific lipocalin-8; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis. (175 aa)    
Predicted Functional Partners:
LCN9
Epididymal-specific lipocalin-9; Lipocalin 9.
   
  
 0.880
CST11
Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family.
   
  
 0.819
LCN6
Epididymal-specific lipocalin-6; May play a role in male fertility.
 
 
  
 0.809
LCN10
Epididymal-specific lipocalin-10; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.
   
  
 0.761
OBP2A
Odorant binding protein 2A; Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.677
LCN12
Epididymal-specific lipocalin-12; Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity).
   
  
 0.672
OVCH2
Ovochymase-2; Ovochymase 2.
   
  
 0.626
LCN1
Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.605
LCN15
Lipocalin-15; Lipocalin 15.
   
  
 0.580
CST8
Cystatin-8; Performs a specialized role during sperm development and maturation.
   
  
 0.576
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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