| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM10 | LCTL | ENSP00000260408 | ENSP00000343490 | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at '76- Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cl [...] | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | 0.485 |
| ADAM10 | TRPV5 | ENSP00000260408 | ENSP00000265310 | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at '76- Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cl [...] | Transient receptor potential cation channel subfamily V member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 hete [...] | 0.521 |
| FGF23 | LCTL | ENSP00000237837 | ENSP00000343490 | Fibroblast growth factor 23 C-terminal peptide; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | 0.660 |
| FGF23 | TRPV5 | ENSP00000237837 | ENSP00000265310 | Fibroblast growth factor 23 C-terminal peptide; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. | Transient receptor potential cation channel subfamily V member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 hete [...] | 0.827 |
| GINM1 | LCTL | ENSP00000356389 | ENSP00000343490 | Glycoprotein integral membrane 1. | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | 0.493 |
| ITGA8 | LCTL | ENSP00000367316 | ENSP00000343490 | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | 0.701 |
| ITGA8 | SUSD5 | ENSP00000367316 | ENSP00000308727 | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. | Sushi domain containing 5. | 0.486 |
| LCTL | ADAM10 | ENSP00000343490 | ENSP00000260408 | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at '76- Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cl [...] | 0.485 |
| LCTL | FGF23 | ENSP00000343490 | ENSP00000237837 | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | Fibroblast growth factor 23 C-terminal peptide; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. | 0.660 |
| LCTL | GINM1 | ENSP00000343490 | ENSP00000356389 | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | Glycoprotein integral membrane 1. | 0.493 |
| LCTL | ITGA8 | ENSP00000343490 | ENSP00000367316 | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. | 0.701 |
| LCTL | LENEP | ENSP00000343490 | ENSP00000376278 | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | Lens epithelial cell protein LEP503; May play a role in lens epithelial cell differentiation. | 0.588 |
| LCTL | LGSN | ENSP00000343490 | ENSP00000359691 | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | 0.498 |
| LCTL | SMIM12 | ENSP00000343490 | ENSP00000428585 | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | Small integral membrane protein 12. | 0.513 |
| LCTL | SNAPC5 | ENSP00000343490 | ENSP00000319597 | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | snRNA-activating protein complex subunit 5; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. | 0.501 |
| LCTL | SUSD5 | ENSP00000343490 | ENSP00000308727 | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | Sushi domain containing 5. | 0.582 |
| LCTL | TRPV5 | ENSP00000343490 | ENSP00000265310 | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | Transient receptor potential cation channel subfamily V member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 hete [...] | 0.752 |
| LENEP | LCTL | ENSP00000376278 | ENSP00000343490 | Lens epithelial cell protein LEP503; May play a role in lens epithelial cell differentiation. | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | 0.588 |
| LENEP | LGSN | ENSP00000376278 | ENSP00000359691 | Lens epithelial cell protein LEP503; May play a role in lens epithelial cell differentiation. | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | 0.641 |
| LGSN | LCTL | ENSP00000359691 | ENSP00000343490 | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. | 0.498 |
